Yes - a hearty amen to this! My misgiving about that paper is that the direct antiviral effects they're reporting occur at concentrations a thousand times higher than the concentration of Claritin in the bloodstream after a dose. On the other hand a shot of over the counter azelastine nasal spray might at least transiently be high enough to give direct antiviral effects (if the infection is restricted to the sinuses, as I suspect mine was).
The bet I think Yu et al are missing is that Spike is engaging histamine receptor H1 (HRH1) specifically for the purpose of triggering it. With the idea that triggering HRH1 could essentially be a form of immune evasion (not to mention making you sneeze virions all over the place).
I appreciate the comment - seeing that great minds are thinking alike on this stuff encourages me to hope that I might be onto something with my IL-4 unified field theory of what the hell just happened to me. Watch this space - I'll look forward to you finding flaws in my thinking in a series of more detailed posts coming this week.
I don't have strong feelings about the dose - but I probably wouldn't want to take as much as Ujjan study used on a long-term daily basis. Going forward, I'll probably just pop a Nasafytol once in awhile when I think of it. I also happen to really enjoy foods that are naturally quercetin- and curcumin-rich, so hopefully that will do more of the heavy lifting than pills.
Anyway, watch this space. I feel like I'm converging on sort of a unified field theory for how nearly all of my candidate treatments may be working - and the new theory may be helping me intuit doses and combinations I'll employ for myself going forward. I'm glad Substack isn't my day job because I'm a very slow writer. But hopefully just another week or so before the detailed posts go up.
Re: antihistamines, this quite recent paper seems to say loratadine (Claritin) may also work:
https://journals.asm.org/doi/10.1128/mbio.01088-24
Seems a pretty good candidate for the "cheap and easy prophylactic" list if so.
Yes - a hearty amen to this! My misgiving about that paper is that the direct antiviral effects they're reporting occur at concentrations a thousand times higher than the concentration of Claritin in the bloodstream after a dose. On the other hand a shot of over the counter azelastine nasal spray might at least transiently be high enough to give direct antiviral effects (if the infection is restricted to the sinuses, as I suspect mine was).
The bet I think Yu et al are missing is that Spike is engaging histamine receptor H1 (HRH1) specifically for the purpose of triggering it. With the idea that triggering HRH1 could essentially be a form of immune evasion (not to mention making you sneeze virions all over the place).
I appreciate the comment - seeing that great minds are thinking alike on this stuff encourages me to hope that I might be onto something with my IL-4 unified field theory of what the hell just happened to me. Watch this space - I'll look forward to you finding flaws in my thinking in a series of more detailed posts coming this week.
What supplements do you take daily? How many mg mint/quercetin
Thanks for the comment! My mint/quercetin thinking hasn't changed too much since this post:
https://cbuck.substack.com/p/viruses-are-supervillains-herbs-are?r=5cli6
For the current infection, I've been occasionally taking a specific brand of quercetin/curcumin called Nasafytol, which is what this study used:
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1023997/full
I don't have strong feelings about the dose - but I probably wouldn't want to take as much as Ujjan study used on a long-term daily basis. Going forward, I'll probably just pop a Nasafytol once in awhile when I think of it. I also happen to really enjoy foods that are naturally quercetin- and curcumin-rich, so hopefully that will do more of the heavy lifting than pills.
Anyway, watch this space. I feel like I'm converging on sort of a unified field theory for how nearly all of my candidate treatments may be working - and the new theory may be helping me intuit doses and combinations I'll employ for myself going forward. I'm glad Substack isn't my day job because I'm a very slow writer. But hopefully just another week or so before the detailed posts go up.